The pituitary gland and the hypothalamus is the one responsible for producing these types of hormones, and acts as the lutienizing agent in controlling its production in the body. As the menopausal stage occurs, it is usually characterized by a full year without menstrual period and the level of estrogen in the body gradually goes down. The production of low estrogen also affects the holistic balance of the woman s body or the homeostasis. Your body will find it difficult to maintain your natural anatomy. Low estrogen in the body also affects the normal function of the brain. There are many studies that tell that estrogen can prevent the existence of Alzheimer s disease. Although the Women s Health initiative did not take in hand this particular query, observational undertakings proved that taking estrogen for quite a while starting in menopausal stage prove to have some health benefits. Among these benefits are: Lower hip fractures Lower cases of heart attacks While the negative effect for long-term intakes over dosage are: Gall stone Breast cancer Endometrial cancer The bottom line is, too much of something is bad for one s well being, even if we talking about a compound with an immense health benefit and wonders- as in the case of estrogen. The hormones should not be used when a woman is pregnant because it can lead to miscarriage. If taken at the earlier stage of pregnancy, it can badly harm the developing fetus. For most senior women, they take the hormone even without any preventive measures. What they do not know is the risk of its side effects increases as they become older and older. That is why regular intake of estrogen supplements in older women is essential. Women who are already on their menopausal stage should take natural estrogen supplements. Studies show that normal estrogen supplement helps in preventing Alzheimer's disease. Alzheimer s disease is common to old age especially to women. Nevertheless, the effect of Estrogen supplement is not always bad because it can really treat hormonal imbalance and is also good for curing diseases such as the menstrual migraine, which is also a symptom of menopause. Among the most common supplement for the Estrogen that achieves hormonal balance is the Premarin.